The study will assess if PET/CT scans can help identify patients who may have better outcomes from adding customized therapy to standard-of-care treatment
De-escalation is an effort to reduce the intensity of treatment without sacrificing efficacy. This issue covers several de-escalation trials: DECREASE, CompassHER2 pCR, and E3311.
This study is evaluating whether lower doses of chemoradiation will be able to effectively treat early-stage anal squamous cell carcinoma while also decreasing side effects.
This study showed that surgery followed by low-dose radiation alone led to very good outcomes, similar to surgery with standard-dose radiation, preserving patients’ throat function and potentially sparing them unnecessary side effects.